Endocrine Abstracts

Background: Although the prognosis inGuillain-Barré syndrome (GBS) is generally good, the protracted and sometimes incomplete recovery is a heavy burden for patients. Animal studies suggest that treatment with growth hormone (GH) could stimulate myelin repair and thus accelerate functional recovery in acute polyneuropathy. We report on the first use of GH in GBS.Objective: To monitor safety and tolerability as well as to evaluate the effect of off-l...

Introduction: Pasireotide is a potent somatostatin analogue (SSA) and used in therapy-refractory acromegaly, commonly after failure of treatment with first-generation SSA. However, it may induce severe hyperglycemia, which usually occurs rapidly after initiation of therapy and in general gradually improves over time. We here present two cases of young male patients who developed severe pasireotide-induced hyperglycemia after several years of treatment.Ca...

Introduction: Acromegaly is a slowly progressing systemic disease that leads to numerous changes in metabolism and organ function. A large cross-sectional study showed signs of subclinical airway obstruction in female patients. We performed a longitudinal study of lung function testing to compare parameters of airway obstruction in male and female patients with acromegaly over time.Methods: 40 patients with acromegaly (24 male, 16 female) underwent repea...

Introduction: Hypophysitis is a frequent side effect of oncologic immunotherapy. The recommended standard treatment is systemic high-dose corticosteroids (HDS), however, recent studies have questioned the benefits of this treatment. We sought to examine the effect of HDS on immunotherapy-induced hypophysitis (IH) in a multi-centric cohort.Methods: Medical records of 41 patients with IH treated by specialist endocrinologists at three tertiary referral cen...